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Enzyme Kinetics : Competitive vs. Non-competitive Inhibition :

With Kompetitive inhibition: Km increases; no change in Vmax.

With Non-kompetitive inhibition: No change in Km; Vmax decreases.

Enzymes: Classification of Enzymes : "TO HILL"
T : Transferases
O : Oxidoreductases
H : Hydrolases
I : Isomerases
L : Ligases
L : Lyases

Enzymes: Competitive Inhibitors : "Competition is hard because we have to travel more kilometers (Km) with the same velocity"
With competitive inhibitors, Velocity remains same but Km increases

Fabry's Disease : "FABRY'S"
F : Foam cells found in glomeruli and tubules/ Febrile episodes
A : Alpha galactosidase A deficiency/ Angiokeratomas
B : Burning pain in extremities/ BUN increased in serum/ Boys R : Renal failure
Y : YX genotype (male, X linked recessive)
S : Sphingolipidoses

G6PD: Oxidant Drugs Inducing Hemolytic Anemia : "AAA"
A : Antibiotic (eg: sufamethoxazole)
A : Antimalarial (eg: primaquine)
A : Antipyretics (eg: acetanilid, but not aspirin or acetaminophen)

Galactosaemia: Enzyme Deficiency: "GALIPUT"
Galactose 1 Phosphate Uridyl Transferase.
There is an assay called the Galiput test for this.

Glycogen Storage: Anderson's (IV) vs. Cori's (III) Enzyme Defect
"ABCD"
Anderson's=Branching enzyme.
Cori's=Debranching enzyme.
Otherwise, cannot really distinguish clinically.

Phenylketonuria: which Enzyme is Deficient : PHenylketonuria is caused by a deficiency of
Phenylalanine Hydroxylase

Pompe's Disease: Type : "Police = Po + lys"
Pompe's disease is a lysosomal storage disease (alpha 1,4 glucosidase).

Pompe's Disease Type Mnemonic , Phenylketonuria which Enzyme is Deficient Mnemonic , Glycogen Storage Mnemonic , Galactosaemia Enzyme Deficiency Mnemonic , G6PD Oxidant Drugs Inducing Hemolytic Anemia Mnemonic , Fabry's Disease Mnemonic , Enzymes Competitive Inhibitors Mnemonic , Enzymes Classification of Enzymes Mnemonic , Enzyme Kinetics Competitive vs. Non-competitive Inhibition Mnemonic

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